cocaine iv self administration

• The Pharmacokinetic Determinants of the Frequency and

  Mar 01 2002  We investigated the pharmacokinetic determinants of the frequency of intravenous cocaine self administration in 2.5 h sessions. Two groups of rats were implanted with dual catheters that permitted cocaine infusion and blood sampling via the femoral and jugular vein catheters respectively. Half of the animals in each group self administered one of

• The sigma 1 receptor modulates dopamine transporter

  A representative cumulative records of an individual subject responding showing patterns of self administration in real time maintained by intravenous cocaine when each fifth response produced an injection fixed ratio or FR 5 response schedule . Ordinates show cumulative responses. Abscissae show time.

• Genetic differences in intravenous cocaine self

  In experiment 2 different mice from the same two strains were allowed to acquire nosepoking for IV cocaine at one of three unit doses 0.5 1.0 or 2.0 mg/kg . Although there were no effects of unit dose on rate of acquisition B6 mice were faster in acquiring self administration behavior than were D2 mice.

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  Cocaine self administration procedure Following recovery from surgery lever trained animals performed cocaine self administration in daily 4 h sessions for 5–6 days/week. A single lever press response FR1 at the active lever produced a 0.5 mg/kg intravenous i.v. injectionofcocainedeliveredin0.1mlover5s concurrent

• Self Administration of Intravenous Medications

  Dec 13 2013  Self administration is a viable and feasible option for patients with chronic diseases requiring administration of intravenous IV medications. According to Healthy People 2020 chronic diseases are the leading cause of death and disability in the United States and in 2008 a reported 107 million Americans almost 1 out of every 2 adults 18

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  agonists attenuate extended access cocaine self

  2014 . However cocaine use disorder is characterized by loss of con trol of cocaine use and augmentation of cocaine consumption along with the passage of time Koob Volkow 2010 . Compared with the short access cocaine self administration the extended access cocaine self administration usually longer than 6 h daily induces the pheno

• Cocaine IV Self Administration

  Cocaine IV Self Administration This protocol outlines the procedure of conducting intravenous cocaine self administration for the GWAS experiment. Timeline of experiment After animal arrival and 2 weeks of This protocol outlines the procedure of conducting intravenous cocaine self administration for the GWAS experiment.

• Intravenous cocaine self administration in rats is reduced

  Mar 01 1990  Intravenous cocaine self administration in rats is reduced by dietary l tryptophan Intravenous cocaine self administration in rats is reduced by dietary l tryptophan Carroll Marilyn Lac Sylvie Asencio Marisel Kragh Rebecca 1990 03 01 00 00 00 213 100 100 3 3 Marilyn E. Carroll Sylvie T. Lac Marisel Asencio Rebecca Kragh Psychiatry Department

• Long Term Cocaine Self Administration Depresses Brain

  Dec 01 2008  Long Term Cocaine Exposure Blunts Temporal Lobe Activity in Monkeys Blue coloring in these images represents areas of the temporal lobe that are less active after cocaine self administration than after food self administration. After 5 days of cocaine self administration left image a monkey still shows normal activity in the temporal lobe area.

• Extended access of cocaine self‐administration results in

  Sep 19 2013  A two way mixed anova revealed a main effect of cocaine self administration on cocaine induced locomotor activity F 1 12 = 27.49 p < 0.0001 Fig. 4a b and a significant Time Self administration interaction F 17 12 = 4.055 p < 0.0001 .

• The relationship between intravenous cocaine self

  Two experiments were conducted to determine whether measures of saccharin intake could be used as a predictor of intravenous cocaine self administration. Saccharin avidity defined as the ratio of total daily fluid intake when saccharin and water were available to total intake when only water was available was measured in male rats. Cocaine

• Reduced Cocaine Self Administration in Muscarinic M5

  Sep 07 2005  The reinforcing effects of cocaine have been related to increased extracellular concentrations of dopamine in the ventral striatum. Several studies suggest that M5 muscarinic receptors facilitate striatal dopamine release. We tested the hypothesis that the reinforcing effects of cocaine are decreased in M5 receptor deficient mice using chronic intravenous cocaine

• The role of glucagon‐like peptide 1 GLP‐1 in addictive

  Self‐administration of cocaine and expectancy of cocaine injections increased endogenous GLP‐1 in rats You et al. 2019 . In contrast a human study reported decreased GLP‐1 levels 1 h after intravenous cocaine injection in experienced cocaine users Bouhlal et al. 2017 .

• PET Imaging in Cocaine Self Administration

  Jul 04 2014  PET Imaging in Cocaine Self Administration The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

• Acquisition of IV amphetamine and cocaine self

  Sep 01 1997  The effect of dose on the acquisition of IV amphetamine and cocaine self administration was examined. Three unit doses of amphetamine 0.03 0.06 and 0.12 mg/kg and three unit doses of cocaine 0.05 0.2 and 0.8 mg/kg were tested in separate groups of ten amphetamine or 13 cocaine rats. Autoshaping methods were used to train rats to press a

• Withdrawal from cocaine self administration produces long

  Figure 1. Cocaine self administration and incubation of cocaine craving. A Mean ± SEM number of cocaine infusions responses both infusion timeout responses on the active cocaine lever and responses on the inactive lever during the three 1 h cocaine self administration sessions. B Total responding per hour on the active and the inactive levers in

• ± Modafinil potentiates cocaine self administration but

  RESULTS A two way repeated measures ANOVA yielded significant effects Methylphenidate but not modafinil sustains intravenous of cocaine dose F4 60 = 7.90 p < 0.001 presession treatment self administration dose of modafinil F3 60 = 8.83 p < 0.001 and a significant Average response rates maintained by cocaine were a bell shaped

• Sex differences in the escalation of intravenous cocaine

  Animals were given LgA or ShA to intravenous cocaine 0.5 mg/kg/infusion self administration under an Fr 1 schedule for 21 days. Subsequently access conditions were made equal 3 h across groups and dose response curves for cocaine were compared.

• Escalation of i.v

  Jun 01 2006  Read Escalation of i.v. cocaine self administration and reinstatement of cocaine seeking behavior in rats bred for high and low saccharin intake Psychopharmacology on DeepDyve the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

• Cocaine Self Administration Produces Long Lasting

  Jul 27 2016  Introduction. Cocaine addiction is a debilitating neurological disorder that results in severe negative health and economic outcomes O Connor et al. 2014 .In the United States alone >700 000 people received treatment for cocaine use in 2014 Substance Abuse and Mental Health Services Administration 2015 .The disorder is characterized by repeated

• Intravenous self administration of cocaine and norcocaine

  The potency of cocaine relative to d amphetamine to initiate and maintain intravenous self administration behavior by dogs n = 5 was determined. Response contingent infusions of cocaine at unit doses of 0.15 0.30 and 0.60 mg/kg/infusion and d amphetamine at unit doses of 0.05 and 0.10 mg/kg/infusion were available during daily 4 h

• NMDA receptors in the nucleus accumbens modulate

  Investigated the role of endogenous glutamate neurotransmission within the nucleus accumbens NAC in the modulation of iv cocaine and heroin self administration in 23 male rats. The selective N methyl D aspartate NMDA receptor antagonist 2 amino 5 phosphonovaleric acid APV was microinfused within the NAC of the ventral striatum of rats trained to lever press for

• The Relationship Between Intravenous Cocaine Self

  Cocaine self administration 0.4 mg/kg/infusion was subsequently measured in an initial 18 h session followed by daily 1 h sessions in which the infusion dose

• Rat IV Self Administration One Compound

  Rat IV Self Administration One Compound. Our infusion swivels tethers balance arms and catheters are compatible with a range of operant behavior systems for intravenous self administration studies. In these systems a lever press or nose poke will trigger a syringe pump to deliver an IV dose.

• Effects of Cocaine Self Administration on Dendritic Spine

  Aug 21 2013  Cocaine self administration had no effect on any of the branch complexity related parameters analyzed P < 0.001 LEW versus F344 rats main effect of strain in ANOVA n = 6 per group . No significant effect of cocaine self administration was observed on any of the morphological parameters in either LEW or F344 rats.